Xenogeneic humoral graft-Vs-host disease following hamster-to-Rat bone marrow transplantation.

BONE marrow transplantation (BMT) is an effective strategy to induce tolerance across xenogeneic barriers.l This approach has been used in the hamster-to-rat BMT model.2 However, all animals suffered from graft-vshost disease (GVHD). Although xenogeneic GVHD has been observed in other studies, it is not yet well characterized.3 Because xenograft rejection is primarily mediated by humoral mechanisms, we tested the hypothesis that, unlike allogeneic GVHD in which cellular mechanisms predominate, xenogeneic GVHD could also be humorally mediated.